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Human Factors: The Journal of the Human Factors and Ergonomics Society
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The Influence of Stimulants, Sedatives, and Fatigue on Tunnel Vision: Risk Factors for Driving and Piloting

Kenneth C. Mills

Profile Associates, Chapel Hill, North Carolina

Susan E. Spruill

PPD Development, Morrisville, North Carolina

Roy W. Kanne

Profile Associates, Chapel Hill, North Carolina

Katherine M. Parkman

Profile Associates, Chapel Hill, North Carolina

Ying Zhang

PPD Development, Morrisville, North Carolina

A computerized task was used in two studies to examine the influence of stimulants, sedatives, and fatigue on single-target and divided-attention responses in different parts of the visual field. The drug effects were evaluated over time with repeated behavioral and subjective measures against ascending and descending drug levels. In the first study, 18 fully rested participants received placebo, alprazolam (0.5 mg), and dextroamphetamine (10 mg). Alprazolam impairs performance, whereas dextroamphetamine induces enhancement and tunnel vision. Study 2 exposed 32 participants to fatigue and no fatigue with a repeated-measures crossover design. Four independent groups subsequently received placebo, dextroamphetamine (10 mg), caffeine (250 mg), or alcohol (.07%). Under fatigue, stimulants have no performance-enhancing effects, whereas impairment from alcohol is severe. Under no fatigue, alcohol has a modest effect, caffeine has no effect, and dextroamphetamine significantly enhances divided-attention performance coincident with tunnel vision. Participants rate all drug effects more stimulating and less sedating while fatigued. Implications for transportation safety are discussed. Actual or potential applications of this research include driver and pilot training.

Human Factors: The Journal of the Human Factors and Ergonomics Society, Vol. 43, No. 2, 310-327 (2001)
DOI: 10.1518/001872001775900878


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